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Opposing MMP-9 Expression in Mesenchymal Stromal Cells and Head and Neck Tumor Cells after Direct 2D and 3D Co-Culture

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Waltera, Anna ; Schulz, Daniela ; Schaefer, Nicole ; Stoeckl, Sabine ; Pion, Eric ; Haerteis, Silke ; Reichert, Torsten E. ; Ettl, Tobias ; Bauer, Richard J.
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Jan 2023 13:41


Bone marrow-derived mesenchymal stromal cells (BMSCs) respond to a variety of tumor cell-derived signals, such as inflammatory cytokines and growth factors. As a result, the inflammatory tumor microenvironment may lead to the recruitment of BMSCs. Whether BMSCs in the tumor environment are more likely to promote tumor growth or tumor suppression is still controversial. In our experiments, direct ...


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