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Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment

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Schoeppe, Robert ; Babl, Nathalie ; Decking, Sonja-Maria ; Schönhammer, Gabriele ; Siegmund, Andreas ; Bruss, Christina ; Dettmer, Katja ; Oefner, Peter J. ; Frick, Linus ; Weigert, Anna ; Jantsch, Jonathan ; Herr, Wolfgang ; Rehli, Michael ; Renner, Kathrin ; Kreutz, Marina
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 20 Jan 2023 09:56


Introduction: Glutamine deficiency is a well-known feature of the tumor environment. Here we analyzed the impact of glutamine deprivation on human myeloid cell survival and function. Methods: Different types of myeloid cells were cultured in the absence or presence of glutamine and/or with L-methionine-S-sulfoximine (MSO), an irreversible glutamine synthetase (GS) inhibitor. GS expression was ...


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