Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment

URN to cite this document:: urn:nbn:de:bvb:355-epub-535709
DOI to cite this document:: 10.5283/epub.53570

Schoeppe, Robert ; Babl, Nathalie ; Decking, Sonja-Maria ; Schönhammer, Gabriele ; Siegmund, Andreas ; Bruss, Christina ; Dettmer, Katja

; Oefner, Peter J.

; Frick, Linus ; Weigert, Anna ; Jantsch, Jonathan ; Herr, Wolfgang ; Rehli, Michael

; Renner, Kathrin

; Kreutz, Marina

License: Creative Commons Attribution 4.0
PDF - Published Version
(19MB)

Date of publication of this fulltext: 20 Jan 2023 09:56

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Introduction: Glutamine deficiency is a well-known feature of the tumor environment. Here we analyzed the impact of glutamine deprivation on human myeloid cell survival and function. Methods: Different types of myeloid cells were cultured in the absence or presence of glutamine and/or with L-methionine-S-sulfoximine (MSO), an irreversible glutamine synthetase (GS) inhibitor. GS expression was ...