Photocaging of Pyridinylimidazole-Based Covalent JNK3 Inhibitors Affords Spatiotemporal Control of the Binding Affinity in Live Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-537343
DOI to cite this document:: 10.5283/epub.53734

Hoffelner, Beate Sandra ; Andreev, Stanislav

; Plank, Nicole ; Koch, Pierre

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Feb 2023 17:09

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Abstract

The concept of photocaging represents a promising approach to acquire spatiotemporal control over molecular bioactivity. To apply this strategy to pyridinylimidazole-based covalent JNK3 inhibitors, we used acrylamido-N-(4-((4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1H-imidazol-5-yl)pyridin-2-yl)amino)phenyl)benzamide (1) as a lead compound to design novel covalent inhibitors of JNK3 by ...