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Donhauser, Ferdinand J. ; Zimmermann, Martina E. ; Steinkirchner, Anna B. ; Wiegrebe, Simon ; Dietl, Alexander ; Brandl, Caroline ; Burkhardt, Ralph ; Gessner, André ; Schweda, Frank ; Bergler, Tobias ; Schäffner, Elke ; Böger, Carsten A. ; Kronenberg, Florian ; Luchner, Andreas ; Stark, Klaus J. ; Heid, Iris M.

Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study

Donhauser, Ferdinand J., Zimmermann, Martina E. , Steinkirchner, Anna B., Wiegrebe, Simon, Dietl, Alexander, Brandl, Caroline , Burkhardt, Ralph , Gessner, André, Schweda, Frank, Bergler, Tobias, Schäffner, Elke , Böger, Carsten A., Kronenberg, Florian , Luchner, Andreas, Stark, Klaus J. and Heid, Iris M. (2023) Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study. Journal of Clinical Medicine 12 (6), p. 2102.

Date of publication of this fulltext: 08 Mar 2023 14:56
Article
DOI to cite this document: 10.5283/epub.53910


Abstract

Cardiovascular risk factors such as high glucose, LDL-cholesterol, blood pressure, and impaired kidney function are particularly frequent in old-aged individuals. However, population-based data on the extent of cardiovascular risk factor control in the old-aged population is limited. AugUR is a cohort of the mobile "70+"-year-old population of/near Regensburg, recruited via population registries. ...

Cardiovascular risk factors such as high glucose, LDL-cholesterol, blood pressure, and impaired kidney function are particularly frequent in old-aged individuals. However, population-based data on the extent of cardiovascular risk factor control in the old-aged population is limited. AugUR is a cohort of the mobile "70+"-year-old population of/near Regensburg, recruited via population registries. We conducted cross-sectional analyses assessing the proportion of AugUR participants with LDL-cholesterol, HbA1c, or blood pressure beyond recommended levels and their association with impaired creatinine- and cystatin-based estimated glomerular filtration rate (eGFR, <60 mL/min/1.73 m(2)) or urine albumin-creatinine ratio (UACR, >= 30 mg/g). Among 2215 AugUR participants, 74.7% were taking lipid-, glucose-, blood-pressure-lowering, or diuretic medication. High LDL-cholesterol at >= 116 mg/dL was observed for 76.1% (51.1% among those with prior cardiovascular events). We found HbA1c >= 7.0% for 6.3%, and high or low systolic blood pressure for 6.8% or 26.5%, respectively (>= 160, <120 mmHg). Logistic regression revealed (i) high HbA1c levels associated with increased risk for impaired kidney function among those untreated, (ii) high blood pressure with increased UACR, and (iii) low blood pressure with impaired eGFR, which was confined to individuals taking diuretics. Our results provide important insights into cardiovascular risk factor control in individuals aged 70-95 years, which are understudied in most population-based studies.



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Details

Item typeArticle
Journal or Publication TitleJournal of Clinical Medicine
Publisher:MDPI
Open Access Type:Gold (with APC)
Place of Publication:BASEL
Volume:12
Number of Issue or Book Chapter:6
Page Range:p. 2102
Date7 March 2023
InstitutionsMedicine > Lehrstuhl für Augenheilkunde
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Abteilung für Nephrologie
Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda
Identification Number
ValueType
10.3390/jcm12062102DOI
KeywordsDENSITY-LIPOPROTEIN CHOLESTEROL; GERMAN HEALTH INTERVIEW; BLOOD-PRESSURE; ADULTS; OLDER; ASSOCIATION; PREVALENCE; MANAGEMENT; MORTALITY; COHORT; LDL-cholesterol; HbA1c; blood pressure; estimated glomerular filtration rate; urine albumin to creatinine ratio; elderly population
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-539101
Item ID53910

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