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Donhauser, Ferdinand J. ; Zimmermann, Martina E. ; Steinkirchner, Anna B. ; Wiegrebe, Simon ; Dietl, Alexander ; Brandl, Caroline ; Burkhardt, Ralph ; Gessner, André ; Schweda, Frank ; Bergler, Tobias ; Schäffner, Elke ; Böger, Carsten A. ; Kronenberg, Florian ; Luchner, Andreas ; Stark, Klaus J. ; Heid, Iris M.

Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study

Donhauser, Ferdinand J., Zimmermann, Martina E. , Steinkirchner, Anna B., Wiegrebe, Simon, Dietl, Alexander, Brandl, Caroline , Burkhardt, Ralph , Gessner, André, Schweda, Frank, Bergler, Tobias, Schäffner, Elke , Böger, Carsten A., Kronenberg, Florian , Luchner, Andreas, Stark, Klaus J. und Heid, Iris M. (2023) Cardiovascular Risk Factor Control in 70- to 95-Year-Old Individuals: Cross-Sectional Results from the Population-Based AugUR Study. Journal of Clinical Medicine 12 (6), S. 2102.

Veröffentlichungsdatum dieses Volltextes: 08 Mrz 2023 14:56
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.53910


Zusammenfassung

Cardiovascular risk factors such as high glucose, LDL-cholesterol, blood pressure, and impaired kidney function are particularly frequent in old-aged individuals. However, population-based data on the extent of cardiovascular risk factor control in the old-aged population is limited. AugUR is a cohort of the mobile "70+"-year-old population of/near Regensburg, recruited via population registries. ...

Cardiovascular risk factors such as high glucose, LDL-cholesterol, blood pressure, and impaired kidney function are particularly frequent in old-aged individuals. However, population-based data on the extent of cardiovascular risk factor control in the old-aged population is limited. AugUR is a cohort of the mobile "70+"-year-old population of/near Regensburg, recruited via population registries. We conducted cross-sectional analyses assessing the proportion of AugUR participants with LDL-cholesterol, HbA1c, or blood pressure beyond recommended levels and their association with impaired creatinine- and cystatin-based estimated glomerular filtration rate (eGFR, <60 mL/min/1.73 m(2)) or urine albumin-creatinine ratio (UACR, >= 30 mg/g). Among 2215 AugUR participants, 74.7% were taking lipid-, glucose-, blood-pressure-lowering, or diuretic medication. High LDL-cholesterol at >= 116 mg/dL was observed for 76.1% (51.1% among those with prior cardiovascular events). We found HbA1c >= 7.0% for 6.3%, and high or low systolic blood pressure for 6.8% or 26.5%, respectively (>= 160, <120 mmHg). Logistic regression revealed (i) high HbA1c levels associated with increased risk for impaired kidney function among those untreated, (ii) high blood pressure with increased UACR, and (iii) low blood pressure with impaired eGFR, which was confined to individuals taking diuretics. Our results provide important insights into cardiovascular risk factor control in individuals aged 70-95 years, which are understudied in most population-based studies.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftJournal of Clinical Medicine
Verlag:MDPI
Ort der Veröffentlichung:BASEL
Band:12
Nummer des Zeitschriftenheftes oder des Kapitels:6
Seitenbereich:S. 2102
Datum7 März 2023
InstitutionenMedizin > Lehrstuhl für Augenheilkunde
Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medizin > Abteilung für Nephrologie
Medizin > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Medizin > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Medizin > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Biologie und Vorklinische Medizin > Institut für Physiologie > Prof. Dr. Frank Schweda
Identifikationsnummer
WertTyp
10.3390/jcm12062102DOI
Stichwörter / KeywordsDENSITY-LIPOPROTEIN CHOLESTEROL; GERMAN HEALTH INTERVIEW; BLOOD-PRESSURE; ADULTS; OLDER; ASSOCIATION; PREVALENCE; MANAGEMENT; MORTALITY; COHORT; LDL-cholesterol; HbA1c; blood pressure; estimated glomerular filtration rate; urine albumin to creatinine ratio; elderly population
Dewey-Dezimal-Klassifikation600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-539101
Dokumenten-ID53910

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