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Monitoring the Reversibility of GPCR Signaling by Combining Photochromic Ligands with Label-free Impedance Analysis

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Wirth, Ulrike ; Erl, Julia ; Azzam, Saphia ; Hoering, Carina ; Skiba, Michael ; Singh, Ritu ; Hochmuth, Kathrin ; Keller, Max ; Wegener, Joachim ; König, Burkhard
Date of publication of this fulltext: 25 Apr 2023 05:09

This publication is part of the DEAL contract with Wiley.


G protein-coupled cell surface receptors (GPCR) trigger complex intracellular signaling cascades upon agonist binding. Classic pharmacological assays provide information about binding affinities, activation or blockade at different stages of the signaling cascade, but real time dynamics and reversibility of these processes remain often disguised. We show that combining photochromic NPY receptor ...


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