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7-Substituted 4-Hydroxychinoline-3-carboxylic Acids as Inhibitors of Dehydrogenase Enzymes and of the Respiration of Ehrlich Ascites Tumor Cells: Multivariate Analysis and Quantitative Structure-Activity Relationships for Polar Substitutens

Dove, Stefan ; Coats, E. ; Scharfenberg, P. ; Franke, R.



Abstract

The title compds. I (R = Cl, OH, CO2H, SO2NH2, etc.) were evaluated for inhibitory activity against malate dehydrogenase [9001-64-3] of the mitochondria and cytoplasm, against muscle lactate dehydrogenase [9001-60-9], and against Ehrlich ascites tumor cells by principal component anal. The results show that enzyme inhibition and inhibition of Ehrlich ascites respiration are not directly ...

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