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Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Vancomycin in Patients with External Ventricular Drain

Chen, Zhendong ; Taubert, Max ; Chen, Chunli ; Dokos, Charalambos ; Fuhr, Uwe ; Weig, Thomas ; Zoller, Michael ; Heck, Suzette ; Dimitriadis, Konstantinos ; Terpolilli, Nicole ; Kinast, Christina ; Scharf, Christina ; Lier, Constantin ; Dorn, Christoph ; Liebchen, Uwe


Vancomycin is a commonly used antibacterial agent in patients with primary central nervous system (CNS) infection. This study aims to examine predictors of vancomycin penetration into cerebrospinal fluid (CSF) in patients with external ventricular drainage and the feasibility of CSF sampling from the distal drainage port for therapeutic drug monitoring. Fourteen adult patients (9 with primary CNS ...


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