UVA-induced metabolic changes in non-malignant skin cells and the potential role of pyruvate as antioxidant

URN to cite this document:: urn:nbn:de:bvb:355-epub-542538
DOI to cite this document:: 10.5283/epub.54253

Ivanova, I.

; Bogner, C. ; Gronwald, W. ; Kreutz, M. ; Kurz, B. ; Maisch, T. ; Kamenisch, Y. ; Berneburg, Mark

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 23 May 2023 04:45

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Abstract

The exposure to UVA (320–400 nm) irradiation is a major threat to human skin concerning photoaging and carcinogenesis. It has been shown that UVA irradiation can induce reactive oxygen species (ROS) and DNA mutations, such as 8-hydroxydeoxyguanosine. Furthermore, UVA induces the expression of photoaging-associated matrix metalloproteases (MMPs), especially of matrix metalloprotease 1 (MMP 1) and ...