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UVA-induced metabolic changes in non-malignant skin cells and the potential role of pyruvate as antioxidant

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Ivanova, I. ; Bogner, C. ; Gronwald, W. ; Kreutz, M. ; Kurz, B. ; Maisch, T. ; Kamenisch, Y. ; Berneburg, Mark
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Date of publication of this fulltext: 23 May 2023 04:45

This publication is part of the DEAL contract with Springer.


The exposure to UVA (320–400 nm) irradiation is a major threat to human skin concerning photoaging and carcinogenesis. It has been shown that UVA irradiation can induce reactive oxygen species (ROS) and DNA mutations, such as 8-hydroxydeoxyguanosine. Furthermore, UVA induces the expression of photoaging-associated matrix metalloproteases (MMPs), especially of matrix metalloprotease 1 (MMP 1) and ...


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