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Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study

Bächle, Helena ; Sekula, Peggy ; Schlosser, Pascal ; Steinbrenner, Inga ; Cheng, Yurong ; Kotsis, Fruzsina ; Meiselbach, Heike ; Stockmann, Helena ; Schönherr, Sebastian ; Eckardt, Kai-Uwe ; Devuyst, Olivier ; Scherberich, Jürgen ; Köttgen, Anna ; Schultheiss, Ulla T ; Eckardt, Kai-Uwe ; Meiselbach, Heike ; Schneider, Markus P ; Schiffer, Mario ; Prokosch, Hans-Ulrich ; Bärthlein, Barbara ; Beck, Andreas ; Reis, André ; Ekici, Arif B ; Becker, Susanne ; Becker-Grosspitsch, Dinah ; Alberth-Schmidt, Ulrike ; Hausknecht, Birgit ; Weigel, Anke ; Walz, Gerd ; Köttgen, Anna ; Schultheiß, Ulla T ; Kotsis, Fruzsina ; Meder, Simone ; Mitsch, Erna ; Reinhard, Ursula ; Floege, Jürgen ; Saritas, Turgay ; Schaeffner, Elke ; Baid-Agrawal, Seema ; Theisen, Kerstin ; Haller, Hermann ; Menne, Jan ; Zeier, Martin ; Sommerer, Claudia ; Theilinger, Johanna ; Wolf, Gunter ; Busch, Martin ; Paul, Rainer ; Sitter, Thomas ; Wanner, Christoph ; Krane, Vera ; Börner-Klein, Antje ; Bauer, Britta ; Kronenberg, Florian ; Raschenberger, Julia ; Kollerits, Barbara ; Forer, Lukas ; Schönherr, Sebastian ; Weissensteiner, Hansi ; Oefner, Peter J. ; Gronwald, Wolfram ; Schmid, Matthias ; Nadal, Jennifer



Abstract

Background. The progression of chronic kidney disease (CKD), a global public health burden, is accompanied by a declining number of functional nephrons. Estimation of remaining nephron mass may improve assessment of CKD progression. Uromodulin has been suggested as a marker of tubularmass.We aimed to identify metabolites associated with uromodulin concentrations in urine and serumto ...

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