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IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

Nanadikar, Maithily S. ; Vergel Leon, Ana M. ; Guo, Jia ; van Belle, Gijsbert J. ; Jatho, Aline ; Philip, Elvina S. ; Brandner, Astrid F. ; Böckmann, Rainer A. ; Shi, Runzhu ; Zieseniss, Anke ; Siemssen, Carla M. ; Dettmer, Katja ; Brodesser, Susanne ; Schmidtendorf, Marlen ; Lee, Jingyun ; Wu, Hanzhi ; Furdui, Cristina M. ; Brandenburg, Sören ; Burgoyne, Joseph R. ; Bogeski, Ivan ; Riemer, Jan ; Chowdhury, Arpita ; Rehling, Peter ; Bruegmann, Tobias ; Belousov, Vsevolod V. ; Katschinski, Dörthe M.


Redox signaling and cardiac function are tightly linked. However, it is largely unknown which protein targets are affected by hydrogen peroxide (H2O2) in cardiomyocytes that underly impaired inotropic effects during oxidative stress. Here, we combine a chemogenetic mouse model (HyPer-DAO mice) and a redox-proteomics approach to identify redox sensitive proteins. Using the HyPer-DAO mice, we ...


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