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On the Evaluation of Structural Activity Patterns

Franke, R. ; Streich, W.-J. ; Dove, Stefan


A review with 14 refs. of the computer methods LOGANA and LOCON which derive topol. pharmacophores by the step-wise combination of topol. descriptors using the logical operations "and", "or" and "not". The application of these methods to study b-blocking agents activity is discussed.

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