Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript

URN to cite this document:: urn:nbn:de:bvb:355-epub-543756
DOI to cite this document:: 10.5283/epub.54375

Höllerer, Simon

; Jeschek, Markus

License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 15 Jun 2023 12:21

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Abstract

Translation is a key determinant of gene expression and an important biotechnological engineering target. In bacteria, 5′-untranslated region (5′-UTR) and coding sequence (CDS) are well-known mRNA parts controlling translation and thus cellular protein levels. However, the complex interaction of 5′-UTR and CDS has so far only been studied for few sequences leading to non-generalisable and partly ...