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Novel Functional Features of cGMP Substrate Proteins IRAG1 and IRAG2

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Prüschenk, Sally ; Majer, Michael ; Schlossmann, Jens
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Date of publication of this fulltext: 15 Jun 2023 12:25


The inositol triphosphate-associated proteins IRAG1 and IRAG2 are cGMP kinase substrate proteins that regulate intracellular Ca2+. Previously, IRAG1 was discovered as a 125 kDa membrane protein at the endoplasmic reticulum, which is associated with the intracellular Ca2+ channel IP3R-I and the PKGIβ and inhibits IP3R-I upon PKGIβ-mediated phosphorylation. IRAG2 is a 75 kDa membrane protein ...


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