Novel Functional Features of cGMP Substrate Proteins IRAG1 and IRAG2

URN to cite this document:: urn:nbn:de:bvb:355-epub-543777
DOI to cite this document:: 10.5283/epub.54377

Prüschenk, Sally ; Majer, Michael

; Schlossmann, Jens

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Jun 2023 12:25

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Abstract

The inositol triphosphate-associated proteins IRAG1 and IRAG2 are cGMP kinase substrate proteins that regulate intracellular Ca2+. Previously, IRAG1 was discovered as a 125 kDa membrane protein at the endoplasmic reticulum, which is associated with the intracellular Ca2+ channel IP3R-I and the PKGIβ and inhibits IP3R-I upon PKGIβ-mediated phosphorylation. IRAG2 is a 75 kDa membrane protein ...