Numerous studies suggest that sleep benefits memory. A major theoretical question in this area is however if sleep does so by passively shielding memories from interference that arises during wakefulness or by actively stabilizing and strengthening memories. A key finding by Ellenbogen et al. Current Biology, 16, 1290-1294 (2006a) indicates that sleep can protect memories from retroactive interference, which suggests that sleep plays more than a passive role for memory consolidation. Sample size in this study was however small and subsequent reports in the literature provided mixed results. We therefore conducted an online study via Zoom to replicate Ellenbogen et al. Current Biology, 16, 1290-1294 (2006a). Subjects were asked to study paired associates. After a 12-h delay that included either nocturnal sleep or daytime wakefulness, half of all subjects were asked to study an additional list to elicit retroactive interference. All participants were then asked to complete a memory test for the studied list(s). The results were fully consistent with those reported by Ellenbogen et al. Current Biology, 16, 1290-1294 (2006a). We discuss this successful replication against the background of the mixed literature, with a focus on the possibly critical role of study-design features, like the use of high learning criteria that resulted in performance being at ceiling, or a confound between interference and the length of the retention interval. A collaborative replication effort may be needed to reach a straightfoward answer to the question if sleep protects memories from interference (and under what conditions).