Go to content
UR Home

Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones

Mahboobi, Siavosh ; Uecker, A. ; Cénac, C. ; Sellmer, A. ; Eichhorn, E. ; Elz, Sigurd ; Böhmer, F.-D. ; Dove, Stefan



Abstract

A series of bis(benzo[b]furan-2-yl)methanones was synthesized and tested for inhibition of FLT3 and PDGFR autophosphorylation. Mostly, C-5 substitution leads to PDGFR selectivity, which was strongest in the case of the 5,5'-dimethoxy deriv. The 5,5'-diamino and the 6,6'-dihydroxy compds. are more active at FLT3. At both kinases, the potency of the best inhibitors approaches IC50 values of ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons