Changes in adenoviral chromatin organization precede early gene activation upon infection

URN to cite this document:: urn:nbn:de:bvb:355-epub-546554
DOI to cite this document:: 10.5283/epub.54655

Schwartz, Uwe

; Komatsu, Tetsuro ; Huber, Claudia ; Lagadec, Floriane ; Baumgartl, Conradin ; Silberhorn, Elisabeth ; Nuetzel, Margit ; Rayne, Fabienne ; Basyuk, Eugenia ; Bertrand, Edouard ; Rehli, Michael

; Wodrich, Harald ; Laengst, Gernot

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 31 Aug 2023 04:59

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Abstract

Within the virion, adenovirus DNA associates with the virus-encoded, protamine-like structural protein pVII. Whether this association is organized, and how genome packaging changes during infection and subsequent transcriptional activation is currently unclear. Here, we combined RNA-seq, MNase-seq, ChIP-seq, and single genome imaging during early adenovirus infection to unveil the structure- and ...