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Similarities of the substrate cleavage catalyzed by proline specific endopeptidase and dipeptidyl peptidase IV

Weidhase, R. ; Welker, P. ; Neubert, K. ; Dove, Stefan ; Yoshimoto, T. ; Tsuru, D. ; Barth, A.



Abstract

Sixteen substrates of the type succinyl-Ala-Ala-pX-anilide and succinyl-Ala-Pro-pX anilide having different substituents (X) in p-position of the aryl residue were synthesized and characterized. The influence of electronic as well as hydrophobic substituent consts., s and p, on the hydrolysis of substrates catalyzed by proline-specific endopeptidase (PSE) was investigated. In the Hansch ...

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