Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line

URN to cite this document:: urn:nbn:de:bvb:355-epub-54807
DOI to cite this document:: 10.5283/epub.5480

Kritzenberger, J. ; Bernhardt, Günther ; Gust, Ronald ; Pistor, Petra ; Schönenberger, Helmut ; Yersin, Hartmut

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Date of publication of this fulltext: 05 Aug 2009 13:50

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Details

Item type:

Article

Journal or Publication Title:

Monatshefte fuer Chemie

Volume:

124

Number of Issue or Book Chapter:

Page Range:

pp. 587-604

Date:

1993

Additional Information (public):

CAN 120:132 1-3 Pharmacology 15663-27-1 (Cisplatin) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, against breast cancer, dichlorobis(cycloalkylamine)platinum complexes comparison with); 38780-35-7P; 38780-36-8P; 38780-37-9P; 38780-38-0P; 41637-13-2P; 62928-48-7P; 76647-86-4P; 151767-48-5P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of, against breast cancer cells, structure in relation to); 94157-27-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with silver nitrate and potassium chloride); 2516-34-9 (Cyclobutylamine); 5452-35-7 (Cycloheptylamine); 7681-11-0 (Potassium iodide) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with dipotassium tetrachloroplatinate); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with potassium iodide and cycloalkyl amines); 765-30-0 (Cyclopropylamine) Role: BIOL (Biological study) (reaction. of, with dipotassium tetraiodoplatinate)

Institutions:

Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry III - Physical Chemistry (Molecular Spectroscopy and Photochemistry) > Prof. Dr. Hartmut Yersin

Identification Number:

Value	Type
1994:132	Other
10.1007/BF00819526	DOI

Keywords:

Neoplasm inhibitors (mammary gland, dichlorobis(cycloalkylamine)platinum(II) complexes as, prepn. of, structure in relation to); Mammary gland (neoplasm, inhibitors, dichlorobis(cycloalkylamine)platinum(II) complexes as, prepn. of, structure in relation to); Molecular structure-biological activity relationship (neoplasm-inhibiting, of dichlorobis(cycloalkylamine)platinum(II) complexes); dichlorobiscycloalkylamineplatinum antitumor prepn structure; biscycloalkylamineplatinum dichloro antitumor prepn structure; platinum cycloalkylamine chloro antitumor prepn structure

Dewey Decimal Classification:

500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences

Status:

Published

Refereed:

Yes, this version has been refereed

Created at the University of Regensburg:

Yes

Item ID:

5480

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Abstract

The syntheses of dichlorobis(cycloalkylamine)platinum(II) complexes with cis and trans cycloalkylamine ligands [cis-PtCl2(C3H5NH2)2 to cis-PtCl2(C8H15NH2)2 and trans-PtCl2(C7H13NH2)2 and trans-PtCl2(C8H15NH2)2 are described. The distinction between cis and trans isomers was achieved by 1H-NMR spectroscopy. The antitumor activity was detd. on the cell proliferation of the human MDA-MB-231 breast ...