Kritzenberger, J, Bernhardt, Günther, Gust, Ronald, Pistor, Petra, Schönenberger, Helmut und Yersin, Hartmut. (1993) Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line. Monatshefte fuer Chemie 124 (5), S. 587-604.
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Zusammenfassung
The syntheses of dichlorobis(cycloalkylamine)platinum(II) complexes with cis and trans cycloalkylamine ligands [cis-PtCl2(C3H5NH2)2 to cis-PtCl2(C8H15NH2)2 and trans-PtCl2(C7H13NH2)2 and trans-PtCl2(C8H15NH2)2 are described. The distinction between cis and trans isomers was achieved by 1H-NMR spectroscopy. The antitumor activity was detd. on the cell proliferation of the human MDA-MB-231 breast ...
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| Dokumentenart: | Artikel | ||||||
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| Datum: | 1993 | ||||||
| Zusätzliche Informationen (Öffentlich): | CAN 120:132 1-3 Pharmacology 15663-27-1 (Cisplatin) Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (antitumor activity of, against breast cancer, dichlorobis(cycloalkylamine)platinum complexes comparison with); 38780-35-7P; 38780-36-8P; 38780-37-9P; 38780-38-0P; 41637-13-2P; 62928-48-7P; 76647-86-4P; 151767-48-5P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of, against breast cancer cells, structure in relation to); 94157-27-4P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reaction with silver nitrate and potassium chloride); 2516-34-9 (Cyclobutylamine); 5452-35-7 (Cycloheptylamine); 7681-11-0 (Potassium iodide) Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with dipotassium tetrachloroplatinate); 10025-99-7 Role: RCT (Reactant), RACT (Reactant or reagent) (reaction of, with potassium iodide and cycloalkyl amines); 765-30-0 (Cyclopropylamine) Role: BIOL (Biological study) (reaction. of, with dipotassium tetraiodoplatinate) | ||||||
| Institutionen: | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer) Chemie und Pharmazie > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry III - Physical Chemistry (Molecular Spectroscopy and Photochemistry) > Prof. Dr. Hartmut Yersin | ||||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | Neoplasm inhibitors (mammary gland, dichlorobis(cycloalkylamine)platinum(II) complexes as, prepn. of, structure in relation to); Mammary gland (neoplasm, inhibitors, dichlorobis(cycloalkylamine)platinum(II) complexes as, prepn. of, structure in relation to); Molecular structure-biological activity relationship (neoplasm-inhibiting, of dichlorobis(cycloalkylamine)platinum(II) complexes); dichlorobiscycloalkylamineplatinum antitumor prepn structure; biscycloalkylamineplatinum dichloro antitumor prepn structure; platinum cycloalkylamine chloro antitumor prepn structure | ||||||
| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||||
| Status: | Veröffentlicht | ||||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||||
| An der Universität Regensburg entstanden: | Ja | ||||||
| Dokumenten-ID: | 5480 |
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