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Dichlorobis(cycloalkylamine)platinum(II) complexes. Structure activity relationship on the human MDA-MB-231 breast cancer cell line

URN to cite this document:
urn:nbn:de:bvb:355-epub-54807
DOI to cite this document:
10.5283/epub.5480
Kritzenberger, J. ; Bernhardt, Günther ; Gust, Ronald ; Pistor, Petra ; Schönenberger, Helmut ; Yersin, Hartmut
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Date of publication of this fulltext: 05 Aug 2009 13:50


Abstract

The syntheses of dichlorobis(cycloalkylamine)platinum(II) complexes with cis and trans cycloalkylamine ligands [cis-PtCl2(C3H5NH2)2 to cis-PtCl2(C8H15NH2)2 and trans-PtCl2(C7H13NH2)2 and trans-PtCl2(C8H15NH2)2 are described. The distinction between cis and trans isomers was achieved by 1H-NMR spectroscopy. The antitumor activity was detd. on the cell proliferation of the human MDA-MB-231 breast ...

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