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Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis
Mueller, Richard, Gust, Ronald, Jennerwein, Margaretha, Reile, Herta, Laske, Reiner, Krischke, Walter, Bernhardt, Günther, Spruss, Thilo, Engel, Juergen und Schönenberger, Helmut (1989) Tumor inhibiting [1,2-bis(fluorophenylethylenediamine]platinum(II) complexes. Part I. Synthesis. European Journal of Medicinal Chemistry 24 (4), S. 341-348.Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:50
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DOI zum Zitieren dieses Dokuments: 10.5283/epub.5483
Zusammenfassung
DL- And meso-NHCH(ClH4X)CH(C6H4X)NH2 (L; X = 2-, 3-, 4-F) were prepd. from meso-1,2-bis(2-hydroxyphenyl)ethylenediamine and XC6H4CHO by a diaza Cope-rearrangement. K2PtX4 (X = Ce, I) reacted with L to give PtX2. PtLI2 reacted with Ag2SO4 or AgNO3 to give [PtL(H2O)2]SO4 (X = 2-, 3-, 4-F) and PtL(NO3)2 (X = 4-F), resp.
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| Dokumentenart | Artikel | ||||||
| Titel eines Journals oder einer Zeitschrift | European Journal of Medicinal Chemistry | ||||||
| Verlag: | Elsevier | ||||||
|---|---|---|---|---|---|---|---|
| Band: | 24 | ||||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 4 | ||||||
| Seitenbereich: | S. 341-348 | ||||||
| Datum | 1989 | ||||||
| Zusätzliche Informationen (Öffentlich) | CAN 112:150598 78-7 Inorganic Chemicals and Reactions 446-52-6 (2-Fluorobenzaldehyde); 456-48-4 (3-Fluorobenzaldehyde); 459-57-4 (4-Fluorobenzaldehyde) Role: RCT (Reactant), RACT (Reactant or reagent) (condensation reaction of, with bis(phenyl)ethylenediamines followed by Cope rearrangement); 58519-80-5 (meso-1,2-Bis(2-hydroxyphenyl)ethylenediamine) Role: RCT (Reactant), RACT (Reactant or reagent) (condensation reactions of, with fluorobenzaldehydes followed by Cope rearrangement); 105856-26-6P; 105856-30-2P; 105856-34-6P; 105990-74-7P; 125859-08-7P; 125859-13-4P; 125859-15-6P; 125859-16-7P; 125948-90-5P; 125948-93-8P; 125948-95-0P; 125948-97-2P; 125948-98-3P; 125949-82-8P Role: BAC (Biological activity or effector, except adverse), BSU (Biological study, unclassified), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. and antitumor activity of); 58520-50-6P; 125448-77-3P; 125448-78-4P; 125448-79-5P; 125448-80-8P; 125448-81-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and hydrolysis of); 125859-11-2P; 125949-84-0P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reactions of, with silver nitrate and sulfate); 125859-09-8P; 125859-10-1P; 125948-91-6P; 125949-83-9P Role: RCT (Reactant), SPN (Synthetic preparation), PREP (Preparation), RACT (Reactant or reagent) (prepn. and reactions of, with silver sulfate); 50648-93-6P; 117903-75-0P; 125448-74-0P; 125448-75-1P; 125448-76-2P; 125459-81-6P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of); 10025-99-7 (Dipotassium tetrachloroplatinate(2-); 14708-56-6 (Dipotassium tetraiodoplatinate(2-) Role: RCT (Reactant), RACT (Reactant or reagent) (reactions of, with bis(fluorophenyl)ethylenediamines) | ||||||
| Institutionen | Chemie und Pharmazie > Institut für Pharmazie > Entpflichtete oder im Ruhestand befindliche Professoren > Prof. Schönenberger Chemie und Pharmazie > Institut für Pharmazie > Lehrstuhl Pharmazeutische / Medizinische Chemie II (Prof. Buschauer) | ||||||
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| Stichwörter / Keywords | Cope rearrangement (of bis(hydroxyphenyl)ethylenediamine reaction products with fluorobenzaldehyde); Neoplasm inhibitors (platinum complexes with bis(fluorophenyl)ethylenediamines); antitumor activity platinum fluorophenylethylenediamine complex platinum fluorophenylethylenediamine diastereoisomer complex ethylenediamine fluorophenyl platinum diastereoisomer complex | ||||||
| Dewey-Dezimal-Klassifikation | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||||
| Status | Veröffentlicht | ||||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||||
| An der Universität Regensburg entstanden | Ja | ||||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-54836 | ||||||
| Dokumenten-ID | 5483 |
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