Structural basis for RNA-duplex unwinding by the DEAD-box helicase DbpA

URN to cite this document:: urn:nbn:de:bvb:355-epub-549550
DOI to cite this document:: 10.5283/epub.54955

Wurm, Jan Philip

License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 03 Nov 2023 10:20

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Abstract

DEAD-box RNA helicases are implicated in most aspects of RNA biology, where these enzymes unwind short RNA duplexes in an ATP-dependent manner. During the central step of the unwinding cycle, the two domains of the helicase core form a distinct closed conformation that destabilizes the RNA duplex, which ultimately leads to duplex melting. Despite the importance of this step for the unwinding ...