Effect of albumin substitution on pharmacokinetics of piperacillin/tazobactam in patients with severe burn injury admitted to the ICU

URN to cite this document:: urn:nbn:de:bvb:355-epub-552105
DOI to cite this document:: 10.5283/epub.55210

Wulkersdorfer, Beatrix ; Bergmann, Felix ; Amann, Lisa ; Fochtmann-Frana, Alexandra ; Al Jalali, Valentin ; Kurdina, Elizaveta ; Lackner, Edith ; Wicha, Sebastian G ; Dorn, Christoph

; Schäfer, Bruno ; Ihra, Gerald ; Rath, Thomas ; Radtke, Christine ; Zeitlinger, Markus

License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 19 Dec 2023 06:58

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Abstract

Background: Pathophysiological changes in severely burned patients alter the pharmacokinetics (PK) of anti-infective agents, potentially leading to subtherapeutic concentrations at the target site. Albumin supplementation, to support fluid resuscitation, may affect pharmacokinetic properties by binding drugs. This study aimed to investigate the PK of piperacillin/tazobactam in burn patients ...