Single sessions of transcranial direct current stimulation and transcranial random noise stimulation exert no effect on sleepiness in patients with narcolepsy and idiopathic hypersomnia

URN to cite this document:

urn:nbn:de:bvb:355-epub-552563 Copy

DOI to cite this document:

10.5283/epub.55256 Copy

Hohenester, Michaela ; Langguth, Berthold ; Wetter, Thomas Christian ; Geisler, Peter ; Schecklmann, Martin ; Reissmann, Andreas

License: Creative Commons Attribution 4.0 PDF - Published Version (561kB)

Date of publication of this fulltext: 20 Dec 2023 14:35

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	3231.8
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	Frontiers in Psychiatry
Publisher:	Frontiers
Volume:	14
Date:	11 December 2023
Institutions:	Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:	Value Type 10.3389/fpsyt.2023.1288976 DOI
Keywords:	anodal tDCS, tRNS, hypersomnia, narcolepsy, idiopathic hypersomnia, vigilance, sleepiness
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	55256

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Abstract

Background: Hypersomnia poses major challenges to treatment providers given the limitations of available treatment options. In this context, the application of non-invasive brain stimulation techniques such as transcranial electrical stimulation (tES) may open up new avenues to effective treatment. Preliminary evidence suggests both acute and longer-lasting positive effects of transcranial direct ...

Abstract

Background: Hypersomnia poses major challenges to treatment providers given the limitations of available treatment options. In this context, the application of non-invasive brain stimulation techniques such as transcranial electrical stimulation (tES) may open up new avenues to effective treatment. Preliminary evidence suggests both acute and longer-lasting positive effects of transcranial direct current stimulation (tDCS) on vigilance and sleepiness in hypersomniac patients. Based on these findings, the present study sought to investigate short-term effects of single sessions of tDCS and transcranial random noise stimulation (tRNS) on sleepiness in persons suffering from hypersomnia.

Methods: A sample of 29 patients suffering from narcolepsy or idiopathic hypersomnia (IH) was recruited from the Regensburg Sleep Disorder Center and underwent single sessions of tES (anodal tDCS, tRNS, sham) over the left and right dorsolateral prefrontal cortex on three consecutive days in a double-blind, sham-controlled, pseudorandomized crossover trial. The primary study endpoint was the mean reaction time measured by the Psychomotor Vigilance Task (PVT) before and directly after the daily tES sessions. Secondary endpoints were additional PVT outcome metrics as well as subjective outcome parameters (e.g., Karolinska Sleepiness Scale; KSS).

Results: There were no significant treatment effects neither on objective (i.e., PVT) nor on subjective indicators of sleepiness.

Conclusion: We could not demonstrate any clinically relevant effects of single sessions of tDCS or tRNS on objective or subjective measures of sleepiness in patients with hypersomnia. However, we cannot exclude that repeated sessions of tES may affect vigilance or sleepiness in hypersomniac patients.

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Metadata last modified: 14 Feb 2024 09:32

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