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Early Age- and Sex-Dependent Regulation of Astrocyte-Mediated Glutamatergic Synapse Elimination in the Rat Prefrontal Cortex: Establishing an Organotypic Brain Slice Culture Investigating Tool

URN to cite this document:
urn:nbn:de:bvb:355-epub-552575
DOI to cite this document:
10.5283/epub.55257
Vivi, Eugenia ; Seeholzer, Lea R. ; Nagumanova, Anastasiia ; Di Benedetto, Barbara
[img]License: Creative Commons Attribution 4.0
PDF - Published Version
(6MB)
Date of publication of this fulltext: 20 Dec 2023 15:05



Abstract

Clinical and pre-clinical studies of neuropsychiatric (NP) disorders show altered astrocyte properties and synaptic networks. These are refined during early postnatal developmental (PND) stages. Thus, investigating early brain maturational trajectories is essential to understand NP disorders. However, animal experiments are highly time-/resource-consuming, thereby calling for alternative ...

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