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Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases

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Kinateder, Thomas ; Mayer, Carina ; Nazet, Julian ; Sterner, Reinhard
Date of publication of this fulltext: 07 Feb 2024 05:15

This publication is part of the DEAL contract with Wiley.


Advances in sequencing technologies have led to a rapid growth of public protein sequence databases, whereby the fraction of proteins with experimentally verified function continuously decreases. This problem is currently addressed by automated functional annotations with computational tools, which however lack the accuracy of experimental approaches and are susceptible to error propagation. ...


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