Linezolid brain penetration in neurointensive care patients

URN to cite this document:: urn:nbn:de:bvb:355-epub-555398
DOI to cite this document:: 10.5283/epub.55539

Hosmann, Arthur ; Moser, Miriam M ; van Os, Wisse ; Gramms, Leon ; al Jalali, Valentin ; Sanz Codina, Maria ; Plöchl, Walter ; Lier, Constantin ; Kees, Frieder

; Dorn, Christoph

; Rössler, Karl ; Reinprecht, Andrea ; Zeitlinger, Markus

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 Feb 2024 08:19

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Abstract

Background: Linezolid exposure in critically ill patients is associated with high inter-individual variability, potentially resulting in subtherapeutic antibiotic exposure. Linezolid exhibits good penetration into the CSF, but its penetration into cerebral interstitial fluid (ISF) is unknown. Objectives: To determine linezolid penetration into CSF and cerebral ISF of neurointensive care ...