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Dissociation of endocrine responses to the Trier Social Stress Test in Virtual Reality (VR-TSST) by the benzodiazepine alprazolam and the translocator protein 18 kDa (TSPO) ligand etifoxine

Bahr, Lisa-Marie ; Maurer, Franziska ; Weigl, Johannes ; Weber, Kevin ; Melchner, Doris ; Dörfelt, Anett ; Wechsler, Theresa F. ; Bauer, Olivia ; Reinders, Jörg ; Milenkovic, Vladimir M. ; Wetzel, Christian H. ; Wetter, Thomas C. ; Rupprecht, Rainer ; Mühlberger, Andreas ; Nothdurfter, Caroline


Background: Activity of the two major stress systems, the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-adrenal-medullary (SAM) axis, has already been shown to be modulated by different compounds that bind to the central benzodiazepine receptor. Less is known about ligands that modulate the peripheral benzodiazepine receptor - meanwhile known as the translocator protein 18 kDa (TSPO) - ...


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