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Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

Delacher, Michael ; Simon, Malte ; Sanderink, Lieke ; Hotz-Wagenblatt, Agnes ; Wuttke, Marina ; Schambeck, Kathrin ; Schmidleithner, Lisa ; Bittner, Sebastian ; Pant, Asmita ; Ritter, Uwe ; Hehlgans, Thomas ; Riegel, Dania ; Schneider, Verena ; Groeber-Becker, Florian Kai ; Eigenberger, Andreas ; Gebhard, Claudia ; Strieder, Nicholas ; Fischer, Alexander ; Rehli, Michael ; Hoffmann, Petra ; Edinger, Matthias ; Strowig, Till ; Huehn, Jochen ; Schmidl, Christian ; Werner, Jens M. ; Prantl, Lukas ; Brors, Benedikt ; Imbusch, Charles D. ; Feuerer, Markus



Abstract

Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine and human tissue Treg cells defined a conserved, microbiota-independent tissue-repair Treg signature with a prevailing footprint of the ...

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