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In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase
Maria-Solano, Miguel A., Kinateder, Thomas, Iglesias-Fernández, Javier, Sterner, Reinhard and Osuna, Sílvia
(2021)
In Silico Identification and Experimental Validation of Distal Activity-Enhancing Mutations in Tryptophan Synthase.
ACS Catalysis 11 (21), pp. 13733-13743.
Date of publication of this fulltext: 29 Feb 2024 12:26
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| Item type | Article | ||||
| Journal or Publication Title | ACS Catalysis | ||||
| Publisher: | AMER CHEMICAL SOC | ||||
|---|---|---|---|---|---|
| Place of Publication: | WASHINGTON | ||||
| Volume: | 11 | ||||
| Number of Issue or Book Chapter: | 21 | ||||
| Page Range: | pp. 13733-13743 | ||||
| Date | 2021 | ||||
| Institutions | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner | ||||
| Identification Number |
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| Keywords | ALLOSTERIC REGULATION; MULTIENZYME COMPLEX; COMPUTATIONAL TOOLS; CRYSTAL-STRUCTURE; EVOLUTION; SUBUNIT; HYPERTHERMOPHILE; ENSEMBLES; TRPB; tryptophan synthase; distal mutations; allostery; enzyme design; shortest path map; ancestral sequence reconstruction | ||||
| Dewey Decimal Classification | 500 Science > 540 Chemistry & allied sciences | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| Item ID | 56076 |
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