Selective mono-de-O-acetylation of the per-O-acetylated brasilicardin carbohydrate side chain

Abstract

Methanol dried over powdered 4 angstrom molecular sieves can be used for a selective mono-de-O-acetylation of the phenolic acetyl group of the per -O-acetyl protected brasilicardin A carbohydrate side chain. This reaction opens a practical procedure for a synthetic access to derivates of the immunosuppressive and cytotoxic natural product brasilicardin A.