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Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study

Bahls, Martin ; Leitzmann, Michael F. ; Karch, André ; Teumer, Alexander ; Dörr, Marcus ; Felix, Stephan B. ; Meisinger, Christa ; Baumeister, Sebastian E. ; Baurecht, Hansjörg




Abstract

Aims Observational evidence suggests that physical activity (PA) is inversely and sedentarism positively related with cardiovascular disease risk. We performed a two-sample Mendelian randomization (MR) analysis to examine whether genetically predicted PA and sedentary behavior are related to coronary artery disease, myocardial infarction, and ischemic stroke. Methods and results We used single ...

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