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Mahboobi, Siavosh ; Sellmer, Andreas ; Eswayah, Asma ; Elz, Sigurd ; Uecker, Andrea ; Böhmer, Frank-D.

Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole

Article

Mahboobi, Siavosh, Sellmer, Andreas, Eswayah, Asma, Elz, Sigurd, Uecker, Andrea and Böhmer, Frank-D. (2008) Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole. European journal of medicinal chemistry 43 (7), pp. 1444-1453.



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Details

Item typeArticle
Journal or Publication TitleEuropean journal of medicinal chemistry
PublisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of PublicationPARIS
Volume43
Number of Issue or Book Chapter7
Page Rangepp. 1444-1453
Date2008
Date of publication05 Aug 2009 13:50
InstitutionsChemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Identification Number
ValueType
17983688PubMed ID
10.1016/j.ejmech.2007.09.021DOI
Classification
NotationType
Imidazoles/chemistryMESH
Magnetic Resonance SpectroscopyMESH
Pyrimidines/chemistryMESH
Receptors, Platelet-Derived Growth Factor/antagonists & inhibitorsMESH
Spectrometry, Mass, Electrospray IonizationMESH
Structure-Activity RelationshipMESH
KeywordsRECEPTORS; IMATINIB; POTENT; DERIVATIVES; TARGETS; DRUG; PAP; 1H-imidazol-2-ylamine; pyrimidine; receptor tyrosine kinase; PDGFR; bioisosterism
Dewey Decimal Classification600 Technology > 615 Pharmacy
600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgPartially
Item ID5668

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