Go to content
UR Home

Impact of TSPO Receptor Polymorphism on [18F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders

Vettermann, Franziska J. ; Harris, Stefanie ; Schmitt, Julia ; Unterrainer, Marcus ; Lindner, Simon ; Rauchmann, Boris-Stephan ; Palleis, Carla ; Weidinger, Endy ; Beyer, Leonie ; Eckenweber, Florian ; Schuster, Sebastian ; Biechele, Gloria ; Ferschmann, Christian ; Milenkovic, Vladimir M. ; Wetzel, Christian H. ; Rupprecht, Rainer ; Janowitz, Daniel ; Buerger, Katharina ; Perneczky, Robert ; Höglinger, Günter U. ; Levin, Johannes ; Haass, Christian ; Tonn, Joerg C. ; Niyazi, Maximilian ; Bartenstein, Peter ; Albert, Nathalie L. ; Brendel, Matthias



Abstract

TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical relevance of [F-18]GE-180 is still unclear. We evaluated the impact of rs6971-SNP on in vivo [F-18]GE-180 binding in a healthy brain and in pseudo-reference tissue in neuro-oncological and neurodegenerative diseases. ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons