Casarotto, Plinio C. ; Girych, Mykhailo ; Fred, Senem M. ; Kovaleva, Vera ; Moliner, Rafael ; Enkavi, Giray ; Biojone, Caroline ; Cannarozzo, Cecilia ; Sahu, Madhusmita Pryiadrashini ; Kaurinkoski, Katja ; Brunello, Cecilia A. ; Steinzeig, Anna ; Winkel, Frederike ; Patil, Sudarshan ; Vestring, Stefan ; Serchov, Tsvetan ; Diniz, Cassiano R. A. F. ; Laukkanen, Liina ; Cardon, Iseline 
; Antila, Hanna ; Rog, Tomasz ; Piepponen, Timo Petteri ; Bramham, Clive R. ; Normann, Claus ; Lauri, Sari E. ; Saarma, Mart ; Vattulainen, Ilpo ; Castrén, Eero
; Antila, Hanna ; Rog, Tomasz ; Piepponen, Timo Petteri ; Bramham, Clive R. ; Normann, Claus ; Lauri, Sari E. ; Saarma, Mart ; Vattulainen, Ilpo ; Castrén, Eero 
Zusammenfassung
It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepressant responses, has a cholesterol-sensing function that mediates synaptic effects of cholesterol. ...
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