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Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23

Garnier, Sophie ; Harakalova, Magdalena ; Weiss, Stefan ; Mokry, Michal ; Regitz-Zagrosek, Vera ; Hengstenberg, Christian ; Cappola, Thomas P. ; Isnard, Richard ; Arbustini, Eloisa ; Cook, Stuart A. ; van Setten, Jessica ; Calis, Jorg J. A. ; Hakonarson, Hakon ; Morley, Michael P. ; Stark, Klaus ; Prasad, Sanjay K. ; Li, Jin ; O'Regan, Declan P. ; Grasso, Maurizia ; Müller-Nurasyid, Martina ; Meitinger, Thomas ; Empana, Jean-Philippe ; Strauch, Konstantin ; Waldenberger, Melanie ; Marguiles, Kenneth B. ; Seidman, Christine E. ; Kararigas, Georgios ; Meder, Benjamin ; Haas, Jan ; Boutouyrie, Pierre ; Lacolley, Patrick ; Jouven, Xavier ; Erdmann, Jeanette ; Blankenberg, Stefan ; Wichter, Thomas ; Ruppert, Volker ; Tavazzi, Luigi ; Dubourg, Olivier ; Roizes, Gérard ; Dorent, Richard ; de Groote, Pascal ; Fauchier, Laurent ; Trochu, Jean-Noël ; Aupetit, Jean-François ; Bilinska, Zofia T. ; Germain, Marine ; Völker, Uwe ; Hemerich, Daiane ; Raji, Ibticem ; Bacq-Daian, Delphine ; Proust, Carole ; Remior, Paloma ; Gomez-Bueno, Manuel ; Lehnert, Kristin ; Maas, Renee ; Olaso, Robert ; Saripella, Ganapathi Varma ; Felix, Stephan B. ; McGinn, Steven ; Duboscq-Bidot, Laëtitia ; van Mil, Alain ; Besse, Céline ; Fontaine, Vincent ; Blanché, Hélène ; Ader, Flavie ; Keating, Brendan ; Curjol, Angélique ; Boland, Anne ; Komajda, Michel ; Cambien, François ; Deleuze, Jean-Francois ; Dörr, Marcus ; Asselbergs, Folkert W. ; Villard, Eric ; Trégouët, David-Alexandre ; Charron, Philippe



Abstract

Aims: Our objective was to better understand the genetic bases of dilated cardiomyopathy (DCM), a leading cause of systolic heart failure. Methods and results: We conducted the largest genome-wide association study performed so far in DCM, with 2719 cases and 4440 controls in the discovery population. We identified and replicated two new DCM-associated loci on chromosome 3p25.1 [lead ...

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