Lahmy, Ranit ; Hübner, Harald ; Schmidt, Maximilian F. ; Lachmann, Daniel ; Gmeiner, Peter ; König, Burkhard 
Alternative Links zum Volltext:DOIVerlag
Diese Publikation ist Teil des DEAL-Vertrags mit Wiley.
| Dokumentenart: | Artikel |
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| Open Access Art: | DEAL (Wiley) |
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| Titel eines Journals oder einer Zeitschrift: | Chemistry – A European Journal |
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| Verlag: | Wiley |
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| Ort der Veröffentlichung: | WEINHEIM |
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| Band: | 28 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 63 |
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| Datum: | 2022 |
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| Institutionen: | Chemie und Pharmazie > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
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| Identifikationsnummer: | | Wert | Typ |
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| 10.1002/chem.202201515 | DOI |
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| Stichwörter / Keywords: | PROTEIN-COUPLED RECEPTORS; PHOTOSWITCHES; AGONIST; PHOTOPHARMACOLOGY; ARYLAZOPYRAZOLES; ISOMERIZATION; MECHANISMS; CHEMISTRY; DISCOVERY; TARGETS; arylazopyrazoles; fentanyl; mu-opioid receptor; G protein-coupled receptor; photopharmacology |
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| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Ja |
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| Dokumenten-ID: | 57138 |
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Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation. (Eingebracht am 29 Feb 2024 12:52)
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Zusammenfassung
Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant mu-opioid receptor. These ligands can potentially activate or deactivate the receptor when desired by using light. Spatial and temporal control of biological activity allows for application in a diverse range of biological investigations. Photoswitchable ligands have ...
Zusammenfassung
Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant mu-opioid receptor. These ligands can potentially activate or deactivate the receptor when desired by using light. Spatial and temporal control of biological activity allows for application in a diverse range of biological investigations. Photoswitchable ligands have been developed in this work, modelled on the known agonist fentanyl, with the aim of expanding the current "toolbox" of fentanyl photoswitchable ligands. In doing so, ligands have been developed that change geometry (isomerize) upon exposure to light, with varying photophysical and biochemical properties. This variation in properties could be valuable in further studying the functional significance of the mu-opioid receptor.
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