| Item type: | Article | ||||
|---|---|---|---|---|---|
| Höhe Gebühr (aus OpenAPC): | 1805.72 | ||||
| Institution der Zahlung: | FWF - Austrian Science Fund | ||||
| Journal or Publication Title: | Investigative Opthalmology & Visual Science | ||||
| Publisher: | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | ||||
| Place of Publication: | ROCKVILLE | ||||
| Volume: | 63 | ||||
| Number of Issue or Book Chapter: | 5 | ||||
| Page Range: | p. 30 | ||||
| Date: | 2022 | ||||
| Institutions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie | ||||
| Identification Number: |
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| Keywords: | CHRONIC KIDNEY-DISEASE; OXIDATIVE STRESS; INFLAMMATION; CLASSIFICATION; DRUSEN; COHORT; AXIS; relative telomere length; age-related macular degeneration (AMD); mobile elderly population; diseases of late onset | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 57170 |
Web of ScienceAbstract
PURPOSE. Relative telomere length (RTL) is a biomarker for physiological aging. Premature shortening of telomeres is associated with oxidative stress, which is one possible pathway that might contribute to age-related macular degeneration (AMD). We therefore aimed to investigate the association between RTL and AMD in a well-characterized group of elderly individuals.METHODS. We measured RTL in ...
Abstract
PURPOSE. Relative telomere length (RTL) is a biomarker for physiological aging. Premature shortening of telomeres is associated with oxidative stress, which is one possible pathway that might contribute to age-related macular degeneration (AMD). We therefore aimed to investigate the association between RTL and AMD in a well-characterized group of elderly individuals.METHODS. We measured RTL in participants of the AugUR study using a multiplex quanti-tative PCR-based assay determining the ratio between the telomere product and a single -copy gene product (T/S ratio). AMD was assessed by manual grading of color fundus images using the Three Continent AMD Consortium Severity Scale.RESULTS. Among the 2262 individuals 70 to 95 years old (627 with AMD and 1635 with-out AMD), RTL was significantly shorter in individuals with AMD compared to AMD-free participants. In age-and sex-adjusted logistic regression analyses, we observed an 8% higher odds for AMD per 0.1 unit shorter RTL (odds ratio [OR] = 1.08; 95% confi-dence interval [CI], 1.02-1.14; P = 0.005). The estimates remained stable when adjusted for smoking, high-density lipoprotein cholesterol, cardiovascular disease, diabetes, and hypertension. Interestingly, this association was only present in women (OR = 1.14; 95% CI, 1.06-1.23; P < 0.001), but not in men (OR = 1.01; 95% CI, 0.93-1.10; P = 0.76). A significant sex-by-RTL interaction on AMD was detected (P = 0.043).CONCLUSIONS. Our results show an association of RTL with AMD that was restricted to women. This is in line with altered reactive oxygen species levels and higher telomerase activity in women and provides an indication for a sex-differential pathway for oxidative stress and AMD.
Metadata last modified: 29 Feb 2024 12:52
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