Shi, Yuan 
; Cui, Mochen ; Ochs, Katharina ; Brendel, Matthias ; Strübing, Felix L. ; Briel, Nils ; Eckenweber, Florian ; Zou, Chengyu ; Banati, Richard B. ; Liu, Guo-Jun ; Middleton, Ryan J. ; Rupprecht, Rainer ; Rudolph, Uwe ; Zeilhofer, Hanns Ulrich ; Rammes, Gerhard ; Herms, Jochen ; Dorostkar, Mario M.
; Cui, Mochen ; Ochs, Katharina ; Brendel, Matthias ; Strübing, Felix L. ; Briel, Nils ; Eckenweber, Florian ; Zou, Chengyu ; Banati, Richard B. ; Liu, Guo-Jun ; Middleton, Ryan J. ; Rupprecht, Rainer ; Rudolph, Uwe ; Zeilhofer, Hanns Ulrich ; Rammes, Gerhard ; Herms, Jochen ; Dorostkar, Mario M. 
Abstract
Benzodiazepines, used to treat anxiety and sleep disorders, may cause cognitive impairment. Shi et al. demonstrate that this is caused by interaction with the mitochondrial protein TSPO, which drives microglia to excessively remove synapses. Benzodiazepines are widely administered drugs to treat anxiety and insomnia. In addition to tolerance development and abuse liability, their chronic use may ...
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