Microglial Activation and Connectivity in Alzheimer Disease and Aging

URN to cite this document:: urn:nbn:de:bvb:355-epub-576942
DOI to cite this document:: 10.5283/epub.57694

Rauchmann, Boris‐Stephan

; Brendel, Matthias

; Franzmeier, Nicolai

; Trappmann, Lena ; Zaganjori, Mirlind ; Ersoezlue, Ersin

; Morenas‐Rodriguez, Estrella ; Guersel, Selim ; Burow, Lena ; Kurz, Carolin ; Haeckert, Jan

; Tatò, Maia ; Utecht, Julia ; Papazov, Boris ; Pogarell, Oliver ; Janowitz, Daniel ; Buerger, Katharina ; Ewers, Michael ; Palleis, Carla ; Weidinger, Endy ; Biechele, Gloria ; Schuster, Sebastian ; Finze, Anika ; Eckenweber, Florian ; Rupprecht, Rainer ; Rominger, Axel

; Goldhardt, Oliver ; Grimmer, Timo ; Keeser, Daniel

; Stoecklein, Sophia ; Dietrich, Olaf

; Bartenstein, Peter ; Levin, Johannes

; Höglinger, Günter ; Perneczky, Robert

License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 29 Feb 2024 13:02

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Abstract

Objective Alzheimer disease (AD) is characterized by amyloid beta (A beta) plaques and neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also plays a key role, driven by the activation of microglia. A beta and tau pathology appear to spread along pathways of highly connected brain regions, but it remains elusive whether microglial activation follows a similar ...