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Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

Hannan, Katherine M. ; Soo, Priscilla ; Wong, Mei S. ; Lee, Justine K. ; Hein, Nadine ; Poh, Perlita ; Wysoke, Kira D. ; Williams, Tobias D. ; Montellese, Christian ; Smith, Lorey K. ; Al-Obaidi, Sheren J. ; Núñez-Villacís, Lorena ; Pavy, Megan ; He, Jin-Shu ; Parsons, Kate M. ; Loring, Karagh E. ; Morrison, Tess ; Diesch, Jeannine ; Burgio, Gaetan ; Ferreira, Rita ; Feng, Zhi-Ping ; Gould, Cathryn M. ; Madhamshettiwar, Piyush B. ; Flygare, Johan ; Gonda, Thomas J. ; Simpson, Kaylene J. ; Kutay, Ulrike ; Pearson, Richard B. ; Engel, Christoph ; Watkins, Nicholas J. ; Hannan, Ross D. ; George, Amee J.


The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar stress by medi-ating binding of ribosomal proteins to MDM2, resulting in p53 accumulation. Inappropriate pathway activa-tion is implicated in the pathogenesis of ribosomopathies, while drugs selectively activating the pathway are in trials for cancer. Despite this, the molecular mechanism(s) regulating this ...


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