Direkt zum Inhalt

Canzar, Stefan ; Do, Van Hoan ; Jelić, Slobodan ; Laue, Sören ; Matijević, Domagoj ; Prusina, Tomislav

Metric multidimensional scaling for large single-cell datasets using neural networks

Artikel

Canzar, Stefan, Do, Van Hoan, Jelić, Slobodan, Laue, Sören, Matijević, Domagoj und Prusina, Tomislav (2024) Metric multidimensional scaling for large single-cell datasets using neural networks. Algorithms for Molecular Biology 19 (1).

DOI zum Zitieren dieses Dokuments: 10.5283/epub.58424


Zusammenfassung

Metric multidimensional scaling is one of the classical methods for embedding data into low-dimensional Euclidean space. It creates the low-dimensional embedding by approximately preserving the pairwise distances between the input points. However, current state-of-the-art approaches only scale to a few thousand data points. For larger data sets such as those occurring in single-cell RNA ...

Metric multidimensional scaling is one of the classical methods for embedding data into low-dimensional Euclidean space. It creates the low-dimensional embedding by approximately preserving the pairwise distances between the input points. However, current state-of-the-art approaches only scale to a few thousand data points. For larger data sets such as those occurring in single-cell RNA sequencing experiments, the running time becomes prohibitively large and thus alternative methods such as PCA are widely used instead. Here, we propose a simple neural network-based approach for solving the metric multidimensional scaling problem that is orders of magnitude faster than previous state-of-the-art approaches, and hence scales to data sets with up to a few million cells. At the same time, it provides a non-linear mapping between high- and low-dimensional space that can place previously unseen cells in the same embedding.



Beteiligte Einrichtungen


Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftAlgorithms for Molecular Biology
VerlagSpringer
Open Access ArtDEAL (Springer Gold)
Band19
Nummer des Zeitschriftenheftes oder des Kapitels1
Datum11 Juni 2024
Veröffentlichungsdatum18 Jun 2024 06:21
InstitutionenInformatik und Data Science > Fachbereich Bioinformatik > Algorithmische Bioinformatik (Prof. Dr. Stefan Canzar)
Identifikationsnummer
WertTyp
10.1186/s13015-024-00265-3DOI
Stichwörter / KeywordsMetric multidimensional scaling, Neural networks, Large-scale data, Dimensionality reduction, Single-cell RNA-seq, Clustering
Dewey-Dezimal-Klassifikation000 Informatik, Informationswissenschaft, allgemeine Werke > 004 Informatik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenZum Teil
URN der UB Regensburgurn:nbn:de:bvb:355-epub-584242
Dokumenten-ID58424

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