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Pharmacological Profile of Histaprodifens at Four Recombinant Histamine H1 Receptor Species Isoforms

Strasser, Andrea ; Striegl, Birgit ; Wittmann, Hans-Joachim ; Seifert, Roland



Abstract

There are differences in the pharmacological properties of phenylhistamines and histaprodifens between guinea pig histamine H₁ receptor (gpH₁R) and human histamine H₁ receptor (hH₁R). The aim of this study was to analyze species differences in more detail, focusing on histaprodifen derivatives and including the bovine histamine H₁ receptor (bH₁R) and rat histamine H₁ receptor (rH₁). H₁R species ...

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