Liver Regeneration Associated Protein (ALR) Exhibits Antimetastatic Potential in Hepatocellular Carcinoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-589206
DOI to cite this document:: 10.5283/epub.58920

Dayoub, Rania

; Wagner, Hannah ; Bataille, Frauke ; Stöltzing, Oliver ; Spruss, Thilo ; Buechler, Christa ; Schlitt, Hans-Jürgen ; Weiss, Thomas S.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 16 Aug 2024 11:24

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Abstract

Augmenter of liver regeneration (ALR), which is critically important in liver regeneration and hepatocyte proliferation, is highly expressed in cirrhotic livers and hepatocellular carcinomas (HOC). In the current study, the functional role of ALR in hepatocancerogenesis was analyzed in more detail. HepG2 cells, in which the cytosolic 15 kDa ALR isoform was reexpressed stably, (HepG2-ALR) were ...