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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-596672
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.59667
Zusammenfassung
Aconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects. ACOD1-itaconate is essential for macrophage-mediated control of the intracellular pathogen Coxiella (C.) burnetii, which causes Q fever. Two isomers of itaconate, mesaconate and citraconate, have overlapping yet distinct activity on macrophage ...
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