The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients

Quinten, Chantal ; Coens, Corneel ; Ghislain, Irina ; Zikos, Efstathios ; Sprangers, Mirjam A.G. ; Ringash, Jolie ; Martinelli, Francesca ; Ediebah, Divine E. ; Maringwa, John ; Reeve, Bryce B. ; Greimel, Eva ; King, Madeleine T. ; Bjordal, Kristin ; Flechtner, Hans-Henning ; Schmucker-Von Koch, Joseph ; Taphoorn, Martin J.B. ; Weis, Joachim ; Wildiers, Hans ; Velikova, Galina ; Bottomley, Andrew

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Details

Dokumentenart:	Artikel
Titel eines Journals oder einer Zeitschrift:	European Journal of Cancer
Verlag:	ELSEVIER SCI LTD
Ort der Veröffentlichung:	OXFORD
Band:	51
Nummer des Zeitschriftenheftes oder des Kapitels:	18
Seitenbereich:	S. 2808-2819
Datum:	2015
Institutionen:	Philosophie, Kunst-, Geschichts- und Gesellschaftswissenschaften > Institut für Philosophie
Identifikationsnummer:	Wert Typ 10.1016/j.ejca.2015.08.027 DOI
Stichwörter / Keywords:	CLINICAL-TRIALS; INTERNATIONAL-SOCIETY; SWEDISH-POPULATION; ELDERLY-PATIENTS; REFERENCE-VALUES; BREAST-CANCER; OLDER; ONCOLOGY; QUESTIONNAIRE; SURVIVORS; Increasing age; Cancer burden; General population; Normative data; Health-related quality of life
Dewey-Dezimal-Klassifikation:	100 Philosophie und Psychologie > 100 Philosophie 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Ja
Dokumenten-ID:	59907

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Zusammenfassung

Background: Cancer incidence increases exponentially with advancing age, cancer patients live longer than in the past, and many new treatments focus on stabilizing disease and HRQOL. The objective of this study is to examine how cancer affects patients' HRQOL and whether their HRQOL is age-dependent. Methods: Data from 25 EORTC randomized controlled trials was pooled. EORTC QLQ-C30 mean scores ...

Zusammenfassung

Background: Cancer incidence increases exponentially with advancing age, cancer patients live longer than in the past, and many new treatments focus on stabilizing disease and HRQOL. The objective of this study is to examine how cancer affects patients' HRQOL and whether their HRQOL is age-dependent. Methods: Data from 25 EORTC randomized controlled trials was pooled. EORTC QLQ-C30 mean scores for the cancer cohort and five general population cohorts were compared to assess the impact of cancer on patients' HRQOL. Within the cancer cohort, multiple linear regressions (two-sided level P-value = 0.05 adjusted for multiple testing.) were used to investigate the association between age and HRQOL, adjusted for gender, WHO performance status (PS), distant metastasis and stratified by cancer site. A difference of 10 points on the 0-100 scale was considered clinically important. Results: Cancer patients generally have worse HRQOL compared to the general population, but the specific HRQOL domains impaired vary with age. When comparing the cancer versus the general population, young cancer patients had worse financial problems, social and role functioning, while the older cancer groups had more appetite loss. Within the cancer cohort, HRQOL was worse with increasing age for physical functioning and constipation, and better with increasing age for social functioning, insomnia and financial problems (all p < 0.05). Conclusion: HRQOL is impaired in cancer patients compared to the general population, but the impact on specific HRQOL domains varies by age. Within the cancer population, some HRQOL components improve with age while others deteriorate. Optimal care for older cancer patients should target HRQOL domains most relevant to this population. (C) 2015 Elsevier Ltd. All rights reserved.

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