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DNA methylation of the serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli

Frodl, Thomas ; Szyf, Moshe ; Carballedo, Angela ; Ly, Victoria ; Dymov, Sergiy ; Vaisheva, Farida ; Morris, Derek ; Fahey, Ciara ; Meaney, James ; Gill, Michael ; Booij, Linda



Zusammenfassung

Background The aim of the present study was to investigate the association of fMRI blood oxygen-level dependent (BOLD) reactivity with the level of epigenetic methylation of SLC6A4 in blood DNA from a sample of healthy participants and patients with major depressive disorder (MDD). Methods We investigated patients with MDD and healthy controls using fMRI and an emotional attention-shifting task. ...

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