| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | The Journal of Sexual Medicine | ||||
| Verlag: | WILEY-BLACKWELL | ||||
| Ort der Veröffentlichung: | HOBOKEN | ||||
| Band: | 12 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 2 | ||||
| Seitenbereich: | S. 405-415 | ||||
| Datum: | 2015 | ||||
| Institutionen: | Medizin > Lehrstuhl für Innere Medizin II Medizin > Lehrstuhl für Psychiatrie und Psychotherapie Medizin > Lehrstuhl für Urologie | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | EXCESSIVE DAYTIME SLEEPINESS; CORONARY-ARTERY-DISEASE; RESTLESS LEGS SYNDROME; ENDOTHELIAL DYSFUNCTION; RISK-FACTORS; PSYCHOMOTOR VIGILANCE; SEXUAL DYSFUNCTION; VASCULAR-DISEASE; HEART-DISEASE; CLOCK TEST; Erectile Function; Erectile Dysfunction; Sexual Dysfunction; Endothelial Dysfunction; Vigilance Performance; Sustained Attention; Daytime Sleepiness | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 60685 |
Web of ScienceZusammenfassung
IntroductionErectile dysfunction (ED) is frequent in patients with obstructive sleep apnea (OSA) and may act as a surrogate of endothelial dysfunction. Furthermore, impairments of vigilance and sustained attention are also commonly associated with OSA. AimThe purpose of this study was to evaluate whether there is an association between ED and sustained attention deficits. MethodsA prospective ...
Zusammenfassung
IntroductionErectile dysfunction (ED) is frequent in patients with obstructive sleep apnea (OSA) and may act as a surrogate of endothelial dysfunction. Furthermore, impairments of vigilance and sustained attention are also commonly associated with OSA. AimThe purpose of this study was to evaluate whether there is an association between ED and sustained attention deficits. MethodsA prospective cross-sectional cohort of 401 male in-patients undergoing diagnostic polysomnography for suspected OSA and a 25-minute sustained attention test was analyzed. ED was assessed using the 15-item International Index of Erectile Function (IIEF-15) questionnaire. The Epworth Sleepiness Scale (ESS) served as a measure of daytime sleepiness. Main Outcome MeasureSeverity of impaired erectile function (EF) assessed by the IIEF-15, core task parameters of the sustained attention test (i.e., CR: correct reactions; V-CR: variation of correct reactions, CE: commission errors, RT: reaction time; V-RT: variation of reaction times). ResultsThree hundred eighty-one consecutive patients presenting for in-lab polysomnography were included in the analysis. Impaired EF was diagnosed in 246 patients (65%). With increasing impairment of EF, patients scored significantly worse in all vigilance test parameters and demonstrated more severely diminished vigilance (normal EF: 11.9%, moderately impaired EF: 24.1%, and severely impaired EF: 34.9%). Multivariate regression analyses including established risk factors for ED, OSA, or sleepiness revealed a significant independent association between lower scores for EF and impairments on the following vigilance test variables: odds ratio (95% confidence interval) for V-CR: 0.52 (0.34-0.81), CE: 0.87 (0.80-0.95), and V-RT: 0.91 (0.87-0.96). The ESS was independently associated with both measures of performance instability: odds ratio for V-CR: 6.94 (2.97-16.23) and V-RT: 1.28 (1.14-1.44). ConclusionsIn OSA patients, the severity of impaired EF was associated with impaired vigilance performance, independent of other known risk factors for ED or OSA and not mediated by sleepiness. Potentially, the findings suggest a direct relationship between vascular or endothelial dysfunction and impairments in both EF and neurobehavioral cognitive function. Popp R, Kleemann Y, Burger M, Pfeifer M, Arzt M, and Budweiser S. Impaired vigilance is associated with erectile dysfunction in patients with sleep apnea. J Sex Med 2015;12:405-415.
Metadaten zuletzt geändert: 19 Dez 2024 07:49
Altmetric