; Ascari, Giulia ; Zhao, Jing Hua ; Teumer, Alexander ; Winkler, Thomas W. ; Tšernikova, Natalia ; Luan, Jian'an ; Mihailov, Evelin ; Ehret, Georg B. ; Zhang, Weihua ; Lamparter, David
; Esko, Tõnu ; Macé, Aurelien ; Rüeger, Sina
; Bochud, Pierre-Yves
; Barcella, Matteo ; Dauvilliers, Yves
; Benyamin, Beben
; Evans, David M.
; Hayward, Caroline ; Lopez, Mary F.
; Franke, Lude ; Russo, Alessia ; Heid, Iris M.
; Salvi, Erika ; Vendantam, Sailaja ; Arking, Dan E. ; Boerwinkle, Eric ; Chambers, John C. ; Fiorito, Giovanni ; Grallert, Harald ; Guarrera, Simonetta ; Homuth, Georg ; Huffman, Jennifer E. ; Porteous, David
; Moradpour, Darius ; Iranzo, Alex ; Hebebrand, Johannes
; Kemp, John P. ; Lammers, Gert J. ; Aubert, Vincent
; Heim, Markus H.
; Martin, Nicholas G.
; Montgomery, Grant W. ; Peraita-Adrados, Rosa ; Santamaria, Joan ; Negro, Francesco ; Schmidt, Carsten O. ; Scott, Robert A. ; Spector, Tim D. ; Strauch, Konstantin ; Völzke, Henry ; Wareham, Nicholas J. ; Yuan, Wei
; Bell, Jordana T. ; Chakravarti, Aravinda ; Kooner, Jaspal S.
; Peters, Annette
; Matullo, Giuseppe ; Wallaschofski, Henri ; Whitfield, John B. ; Paccaud, Fred ; Vollenweider, Peter
; Bergmann, Sven
; Beckmann, Jacques S.
; Tafti, Mehdi ; Hastie, Nicholas D. ; Cusi, Daniele
; Bochud, Murielle ; Frayling, Timothy M. ; Metspalu, Andres
; Jarvelin, Marjo-Riitta
; Scherag, André
; Smith, George Davey ; Borecki, Ingrid B.
; Rousson, Valentin ; Hirschhorn, Joel N.
; Rivolta, Carlo
; Loos, Ruth J. F. ; Kutalik, Zoltán | Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | PLoS Genetics | ||||
| Verlag: | PUBLIC LIBRARY SCIENCE | ||||
| Ort der Veröffentlichung: | SAN FRANCISCO | ||||
| Band: | 10 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 7 | ||||
| Seitenbereich: | e1004508 | ||||
| Datum: | 2014 | ||||
| Institutionen: | Medizin > Institut für Epidemiologie und Präventivmedizin | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | QUANTITATIVE TRAIT LOCI; LINKAGE ANALYSIS; OBESITY; CHILDREN; ASSOCIATIONS; PENETRANCE; ALCOHOLISM; VARIANCES; FAMILIES; GENES; | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 61352 |

Zusammenfassung
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated ...

Zusammenfassung
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of similar to 4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P < 0.0027) compared to the respective maternal alleles. Real-time PCR experiments of lymphoblastoid cell lines from the CEPH families showed that expression of both genes was dependent on parental origin of the SNPs alleles (P < 0.01). Our scheme opens new opportunities to exploit GWAS data of unrelated individuals to identify POEs and demonstrates that they play an important role in adult obesity.
Metadaten zuletzt geändert: 19 Dez 2024 08:09
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