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Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

Yoneyama, Sachiko ; Guo, Yiran ; Lanktree, Matthew B. ; Barnes, Michael R. ; Elbers, Clara C. ; Karczewski, Konrad J ; Padmanabhan, Sandosh ; Bauer, Florianne ; Baumert, Jens ; Beitelshees, Amber ; Berenson, Gerald S. ; Boer, Jolanda M.A. ; Burke, Gregory ; Cade, Brian ; Chen, Wei ; Cooper-Dehoff, Rhonda M. ; Gaunt, Tom R. ; Gieger, Christian ; Gong, Yan ; Gorski, Mathias ; Heard-Costa, Nancy ; Johnson, Toby ; Lamonte, Michael J. ; Mcdonough, Caitrin ; Monda, Keri L. ; Onland-Moret, N. Charlotte ; Nelson, Christopher P. ; O'Connell, Jeffrey R. ; Ordovas, Jose ; Peter, Inga ; Peters, Annette ; Shaffer, Jonathan ; Shen, Haiqinq ; Smith, Erin ; Speilotes, Liz ; Thomas, Fridtjof ; Thorand, Barbara ; Monique Verschuren, W. M. ; Anand, Sonia S. ; Dominiczak, Anna ; Davidson, Karina W. ; Hegele, Robert A. ; Heid, Iris ; Hofker, Marten H. ; Huggins, Gordon S. ; Illig, Thomas ; Johnson, Julie A. ; Kirkland, Susan ; König, Wolfgang ; Langaee, Taimour Y. ; Mccaffery, Jeanne ; Melander, Olle ; Mitchell, Braxton D. ; Munroe, Patricia ; Murray, Sarah S. ; Papanicolaou, George ; Redline, Susan ; Reilly, Muredach ; Samani, Nilesh J. ; Schork, Nicholas J. ; Van Der Schouw, Yvonne T. ; Shimbo, Daichi ; Shuldiner, Alan R. ; Tobin, Martin D. ; Wijmenga, Cisca ; Yusuf, Salim ; Hakonarson, Hakon ; Lange, Leslie A. ; Demerath, Ellen W ; Fox, Caroline S. ; North, Kari E ; Reiner, Alex P. ; Keating, Brendan ; Taylor, Kira C.



Zusammenfassung

Waist circumference (WC) and waist-to-hip ratio (WHR) are surrogate measures of central adiposity that are associated with adverse cardiovascular events, type 2 diabetes and cancer independent of body mass index (BMI). WC and WHR are highly heritable with multiple susceptibility loci identified to date. We assessed the association between SNPs and BMI-adjusted WC and WHR and unadjusted WC in up ...

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