Dokumentenart: | Artikel | ||||
---|---|---|---|---|---|
Titel eines Journals oder einer Zeitschrift: | Nature Genetics | ||||
Verlag: | NATURE PUBLISHING GROUP | ||||
Ort der Veröffentlichung: | NEW YORK | ||||
Band: | 45 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 6 | ||||
Seitenbereich: | S. 690-696 | ||||
Datum: | 2013 | ||||
Institutionen: | Medizin > Institut für Epidemiologie und Präventivmedizin | ||||
Identifikationsnummer: |
| ||||
Stichwörter / Keywords: | GENOME-WIDE ASSOCIATION; MULTILOCUS GENOTYPE DATA; COMMON VARIANTS; POSITIVE SELECTION; SEQUENCE VARIANTS; HUMAN-POPULATIONS; GENETIC-VARIATION; ADULT OBESITY; FTO GENE; RISK; | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 62533 |
Zusammenfassung
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We ...
Zusammenfassung
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 x 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 x 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 x 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 x 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
Metadaten zuletzt geändert: 19 Dez 2024 08:39