Acyloxybutadiene tricarbonyl iron complexes as enzyme-triggered CO-releasing molecules (ET-CORMs): a structure–activity relationship study

Romanski, Steffen ; Kraus, Birgit ; Guttentag, Miguel ; Schlundt, Waldemar ; Rücker, Hannelore ; Adler, Andreas ; Neudörfl, Jörg-Martin ; Alberto, Roger ; Amslinger, Sabine

; Schmalz, Hans-Günther

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Zusammenfassung

A series of eta(4)-acyloxycyclohexadiene-Fe(CO)(3) complexes was prepared and fully characterized by spectroscopic methods including single crystal X-ray diffraction. For this purpose a new synthetic access to differently acylated 1,3- and 1,5-dienol-Fe(CO)(3) complexes was developed. The enzymatically triggered CO release from these compounds was monitored (detection of CO through GC and/or by ...